How dsRNA are loaded into Argonaut, the major player of human and plant RNAi? This key step is key to the discussion on how improbable would the load of external, gut-derived dsRNA into Argonaut be.
Therefore, for the sake of a fruitful discussion on this subject at Brazilian CTNBio and other distinguished risk assessment commissions, I strongly suggest the careful reading of the paper below.
Small RNA sorting: matchmaking for Argonautes
Benjamin Czech & Gregory J. Hannon
Nat. Rev. Genet. 12(1): 19-31 (2011)